Cubic liquid crystalline nanoparticles containing a polysaccharide from Ulva fasciata with potent antihyperlipidaemic activity

• DOI: 10.1016/j.jsps.2017.12.007
• Publication Date: 2017-12-08T17:14:28Z
• Authors: Azza A. Matloub; Mona M. AbouSamra; Alaa H. Salama; Maha Z. Rizk; Hanan F. Aly; Ghada Ibrahim Fouad
• Keywords: Malondialdehyde

The present study involves the preparation of cubic liquid crystalline nanoparticles (cubsomes) for liver targeting to assess potential a formulated bioactive polysaccharide isolated from hot aqueous extract Ulva fasciata as an alternative natural agent with anti-hyperlipidaemic activity. Cubosomal were prepared by disrupting gel phase and water in presence surfactant. Different lipid matrices stabilizers tested. All formulations nanosize range showed sufficient negative charge inhibit aggregation cubosomes. Drug entrapment efficiencies (EEs%) determined vitro release studies performed. Transmission electron microscopy (TEM) differential scanning calorimetry used analyze loaded cubosomal containing glyceryl monostearate (GMO 2.25 g), poloxamer 407 (0.25 g) 50 mg polysaccharide. A preclinical comparing fluvastatin reference drug hyperlipidaemic rats was conducted. treated polysaccharide- cubosomes significant decreases total cholesterol (TC), triglycerides (TG) (TL) compared untreated HL rats. In addition, oxidative stress antioxidant biomarkers measured Compared rats, cubosome reduction malondialdehyde (MDA), whereas insignificant changes detected nitric oxide (NO), glutathione (GSH) levels capacity (TAC). Further, vascular intercellular adhesion molecules (VCAM, ICAM), myeloperoxidase demonstrated. histopathological examination conducted alterations lesions document biochemical results. conclusion, this demonstrates superiority using regulator such instead fluvastatin.