Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population

• DOI: 10.1016/j.jsps.2019.11.024
• Publication Date: 2019-12-07T02:29:12Z
• Authors: Kara Pala Zeliha; Ozturk Dilek; Oztas Ezgi; Kara Halil; Uras Cihan; Ozhan Gul
• Keywords: Turkish population; Abcg2

Breast cancer is the most common and second leading cause of cancer-related deaths among women. Several genetic environmental factors are known to be involved in breast pathogenesis, but exact etiology this disease complicated not completely understood. We aimed investigate whether gene polymorphisms ABCB1 ABCG2 carrier proteins COX-2 enzyme affect risk.ABCG2 C421A (rs2231142), C3435T (rs1045642), T8473C (rs5275) G306C (rs5277) were genotyped 104 patients 90 healthy controls using a real-time PCR for susceptibility.Patients carrying C421A, CC genotype, had higher risk compared with any A allele (OR = 3.06; 95% CI 1.49-6.25, p 0.0019). The other variants showed no association (p > 0.05). Comparing pathological parameters variants, only, frequency C was significantly lower estrogen receptor-α (ERα) 2.25; CI: 0.75-6.76; 0.041) progesterone receptor (PgR) 3.67; 1.34-10.03; 0.008) positive patients.ABCB1 might represent potential factor Turkish