Pharmacological and computer-aided studies provide new insights into Millettia peguensis Ali (Fabaceae)

• DOI: 10.1016/j.jsps.2020.11.004
• Publication Date: 2020-11-17T07:23:24Z
• Authors: Safaet Alam; Nazim Uddin Emon; Saimon Shahriar; Fahmida Tasnim Richi; Mohammad Rashedul...; Mohammad Nazmul I...; Shahenur Alam Sakib; Amlan Ganguly
• Keywords: ADME; Anti-inflammatory

Millettia peguensis, popular for its ethnopharmacological uses, was employed to evaluate different pharmacological properties in this study. The analgesic studies of the plant have been performed by acetic acid-induced writhing and formalin-induced licking tests respectively, whereas antidiarrheal experiment done castor oil-induced diarrheal test. Besides, antioxidant, cytotoxic, antimicrobial, thrombolytic evaluations were DPPH scavenging with phenol content determination, brine shrimp lethality, disc diffusion clot lysis methods respectively. Moreover, silico study phytoconstituents carried out molecular docking ADME/T analysis. methanol extract peguensis (MEMP) revealed significant biological activity test (p < 0.001) compared standards. Antioxidant assay displayed promising IC50 values (15.96 μg/mL) total (65.27 ± 1.24 mg GAE/g). In cytotoxicity study, LC50 value found be 1.094 μg/mL. MEMP highly sensitive bacteria but less liable lysis. Furthermore, exposed potential binding affinity towards selected receptors, indicated drug likeliness plant. outcomes these findings suggest therapeutic against pain, diarrhea, inflammation, tissue toxicity.