PKD1-Associated Arachnoid Cysts in Autosomal Dominant Polycystic Kidney Disease

• DOI: 10.1016/j.jstrokecerebrovasdis.2021.105943
• Publication Date: 2021-06-25T01:14:02Z
• Authors: Kaori Shigemori; Eiji Higashihara; Masayuki Itoh; Hiroki Yoshida; Kouji Yamamoto; Kikuo Nutahara; Yoshiaki Shiokawa; Shinya Kaname; Mitsuhiro Tambo; Tsuyoshi Yamaguchi; Satoru Taguchi; Tatsuya Yoshioka; Kenichi Yokoyama; Hiroshi Fukuhara
• Keywords: PKD1

<h2>Abstract</h2><h3>Objectives</h3> the prevalence of intracranial aneurysms and arachnoid cysts is higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than general population. A genotype correlation was reported for aneurysms, but it unclear cysts. Therefore, investigated ADPKD. <h3>Materials Methods</h3> were screened by magnetic resonance imaging (MRI), <i>PKD</i> genotypes examined using next-generation sequencing 169 <h3>Results</h3> <i>PKD1</i>-, <i>PKD2</i>- no-mutation identified 137, 24 8 patients, respectively. Intracranial found 34 25 respectively, no significant difference frequency. Genotype, sex, estimated glomerular filtration rate age at ADPKD diagnosis significantly affected brain MRI. The proportional hazard risk analyzed MRI adjusted these four variables 5.0-times <i>PKD1</i> group <i>PKD2</i> (<i>P</i> = 0.0357)<i>,</i> not different 0.1605). Arachnoid diagnosed earlier (54.8 vs 67.7 years, <i>P</i> 0.0231), 0.4738) Kaplan-Meier analysis. <h3>Conclusions</h3> this study demonstrated between mutation. association advanced renal may be due to common factors