Genetic and nongenetic drivers of platelet reactivity in healthy Tanzanian individuals

• DOI: 10.1016/j.jtha.2023.11.014
• Publication Date: 2023-11-27T17:06:31Z
• Authors: Vesla I. Kullaya; Godfrey S. Temba; Nadira Vadaq; Judith Njau; Collins K. Boahen; Bongani B. Nkambule; Florian Thibord; Ming-Huei Chen; Tal Pecht; Furaha Lyamuya; Vinod Kumar; Mihai G. Netea; Blandina T. Mmbaga; Andre van der Ven; Andrew D. Johnson; Quirijn de Mast
• Keywords: 2. Zero hunger; 11. Sustainability; platelets; platelet activation; protease-activated receptors; genetics; Internal Medicine - Radboud University Medical Center; P-selectin; 3. Good health

Platelets play a key role in hemostasis, inflammation, and cardiovascular diseases. Platelet reactivity is highly variable between individuals. The drivers of this variability populations from Sub-Saharan Africa remain largely unknown.