A Phase 1–2 Study of Rovalpituzumab Tesirine in Combination With Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Extensive-Stage SCLC

• DOI: 10.1016/j.jtho.2021.02.022
• Publication Date: 2021-02-27T12:25:52Z
• Authors: Jyoti Malhotra; Petros Nikolinakos; Ticiana Leal; Jonathan Lehman; Daniel Morgensztern; Jyoti D. Patel; John M. Wrangle; Giuseppe Curigliano; Laurent Greillier; Melissa L. Johnson; Neal Ready; Gilles Robinet; Satwant Lally; David Maag; Ricardo Valenzuela; Vincent Blot; Benjamin Besse
• Keywords: 0301 basic medicine; Immunoconjugates; Lung Neoplasms; [SDV.IMM] Life Sciences [q-bio]/Immunology; [SDV.CAN]Life Sciences [q-bio]/Cancer; Antibodies, Monoclonal, Humanized; [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract; Antibodies; MESH: Benzodiazepinones; MESH: Ipilimumab; 03 medical and health sciences; Clinical trials; [SDV.CAN] Life Sciences [q-bio]/Cancer; Monoclonal; 616; Antineoplastic Combined Chemotherapy Protocols; Medicine and Health Sciences; MESH: Immunoconjugates; Humans; Antibody-drug conjugates; Humanized; Benzodiazepinones; MESH: Humans; ICTS (Institute of Clinical and Translational Sciences); Ipilimumab; MESH: Lung Neoplasms; 3. Good health; MESH: Antineoplastic Combined Chemotherapy Protocols; Nivolumab; MESH: Antibodies, Monoclonal, Humanized; MESH: Nivolumab; [SDV.IMM]Life Sciences [q-bio]/Immunology; Small-molecule agents; [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract; Immunotherapy; Lung cancer

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor.This includes access anonymized, individual and trial-level (analysis sets), as well other information (e.g., protocols Clinical Study Reports), long are not part of an ongoing or planned regulatory submission.This requests for trial unlicensed products indications.These can be requested by any qualified researchers who engage in rigorous, independent scientific research, will provided following review approval a research proposal Statistical Analysis Plan (SAP) execution Data Sharing Agreement (DSA).