Reconsidering the Cutoff Value for Sensitive and Refractory Relapses in Extensive-Stage SCLC in the Era of Immunotherapy

• DOI: 10.1016/j.jtho.2023.09.1446
• Publication Date: 2023-09-23T15:24:14Z
• Authors: Masahiro Torasawa; Hidehito Horinouchi; Shogo Nomura; Satoshi Igawa; Maiko Asai; Hidenobu Ishii; Hiroshi Wakui; Ryota Ushio; Tetsuhiko Asao; Yukiko Namba; Ryo Koyama; Daisuke Hayakawa; Isana Katayama; Hironari Matsuda; Shinichi Sasaki; Kazuhisa Takahashi; Yukio Hosomi; Katsuhiko Naoki; Yuichiro Ohe
• Keywords: Cut-off; Refractory (planetary science)

Traditionally, relapsed SCLC has been classified as "sensitive" or "refractory" on the basis of cutoff values (60 90 d) for duration between last chemotherapy and disease progression. Nevertheless, these are not derived from rigorous analytical methods, their applicability to contemporary treatments remains uncertain.