MP33-19 AN EXOME-WIDE ASSOCIATION STUDY REPLICATED FOR PROSTATE CANCER IN KOREAN POPULATION

• DOI: 10.1016/j.juro.2017.02.1015
• Publication Date: 2017-04-03T18:22:39Z
• Authors: Jong Jin Oh; Tae Jin Kim; In Jae Lee; Byund Do Song; Dong Hwan Lee; Yeon Soo Jung; Hak Min Lee; Sung Kyu Hong; Sangchul Lee; Jin-Nyoung Ho; Sungroh Yoon; Soo Ji Lee; Joohon Sung; Seok-Soo Byun
• Keywords: 03 medical and health sciences; 0302 clinical medicine

You have accessJournal of UrologyProstate Cancer: Detection & Screening III1 Apr 2017MP33-19 AN EXOME-WIDE ASSOCIATION STUDY REPLICATED FOR PROSTATE CANCER IN KOREAN POPULATION Jong Jin Oh, Tae Kim, In Jae Lee, Byund Do Song, Dong Hwan Yeon Soo Jung, Hak Min Sung Kyu Hong, Sangchul Jin-Nyoung Ho, Sungroh Yoon, Ji Joohon Sung, and Seok-Soo Byun OhJong Oh More articles by this author , KimTae Kim LeeIn Lee SongByund Song LeeDong JungYeon Jung LeeHak HongSung Hong LeeSangchul HoJin-Nyoung Ho YoonSungroh Yoon LeeSoo SungJoohon ByunSeok-Soo View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1015AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To date, more than 300 susceptibility loci associated with prostate cancer (PCa) been identified mainly from studies European ancestry populations much less contributions Asian populations. As there was a genetic difference according ethnic groups, we performed the first Korean population based exome wide association study for PCa in study. METHODS Our two-stage design. Stage I – 1,001 patients using custom HumanExome BeadChip v1.0 (Illumina Inc) containing 242,186 SNPs. After quality control, genotype data 988 were compared 2,641 normal controls community cohort (KARE). II 5 exome-wide significant lead SNPs (P < 1.0 × 10-4) selected replicated independent (514 548 control). Genotyping these Fluidigm 192.24 Dynamic Array TM IFC Biomark HD systems. construct risk score (GRS), cumulative number alleles calculated an additive model. Then, obtained estimates area under receiver-operating characteristic curve (AUC) evaluate its discriminative ability. RESULTS detected variants (p 8.30E-07) rs1512268 (8p21, NKX3-1), rs1016343 (8q24, PRNCR1), rs7837688 CASC8), rs7501939 (17q12, HNF1B) rs2735839 (19q13, KLK3) (figure 1) mean GRS 4.23 ± 1.44 4.78 1.43 cases. The increased (GRS 6 : OR=1.85, 7 OR=2.11 reference 4) 2). trend increase is very strong (p<0.0001, test trend). predictive accuracy 0.605 (95%CI 0.573-0.637). CONCLUSIONS We detect population, confirmed many previously reported findings build predict effectively. suggest that similarities susceptibilities might be important aspect across © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e424-e425 Advertisement Copyright Permissions© 2017MetricsAuthor Information Expand PDF downloadLoading ...