MP29-16 IMPROVING THE UTILITY OF CLINICAL PHENOTYPING IN INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME: FROM UPOINT TO INPUT

• DOI: 10.1016/j.juro.2017.02.928
• Publication Date: 2017-04-03T18:32:17Z
• Authors: Alice Crane; Jessica Lloyd; Daniel Shoskes
• Keywords: Fulguration; Bladder Pain Syndrome; Urinary urgency

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Interstitial Cystitis II1 Apr 2017MP29-16 IMPROVING THE UTILITY OF CLINICAL PHENOTYPING IN INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME: FROM UPOINT TO INPUT Alice Crane, Jessica Lloyd, and Daniel Shoskes CraneAlice Crane More articles by this author , LloydJessica Lloyd ShoskesDaniel View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.928AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The phenotyping system has proven effective in classifying patients with Urologic Pelvic Pain Syndromes a clinically meaningful way guide therapy. While highly successful men chronic pelvic pain syndrome (CPPS), is more limited Cystitis/Painful Bladder Syndrome (IC/PBS) since definition all Urinary Organ specific phenotype. Furthermore, AUA guidelines recommend sequential tiered approach therapy rather than multimodal scheme. We sought modify be practical efficacious for IC/PBS METHODS developed new phenotype removing domains from adding Hunner's Ulcers (U) domain, these benefit therapies (fulguration, cyclosporine). This yields “INPUT”: Infection, Neurologic/Systemic, Psychosocial, Tenderness Muscles. applied retrospectively our previously validated upointmd.com database. Symptoms were measured Index (GUPI) (valid women). database was searched complete data assess include GUPI. Men included if they reported relieved voiding and/or presence ulcers. Groups compared ANOVA, Mann-Whitney, t test or Chi squared when appropriate correlated Spearman r. RESULTS There 239 patients, 154 female (64%) age range 18-79 (mean 41.8). Incidence Infection 11%, Neurologic/Systemic 51%, Psychosocial 81%, 18% 85%. Mean total 2.46 (range 0-5) 65% had 2 3 positive while only 5% none. stepwise increase GUPI score increasing number (ANOVA differences between groups p<0.0001, Correlation r=0.355 p<0.0001). Presence ulcers increased mean symptom (25.7 vs 29.7, p=0.004) indeed each significantly except Infection. CONCLUSIONS appears replicate validity potential clinical utility CPPS. Patients diversity phenotypes correlate severe symptoms. Since 95% at least 1 domain it may receive up front extra (eg. floor physical therapy, fulguration ulcers) relying on approach. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e386-e387 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Expand PDF downloadLoading ...