Health-Related Quality of Life of People Who Inject Drugs: The Enhancing Treatment of Hepatitis C in Opioid Substitution Settings Engage Study

• DOI: 10.1016/j.jval.2023.10.013
• Publication Date: 2023-11-10T07:20:54Z
• Authors: Qinglu Cheng; Heather Valerio; Evan B. Cunningham; Sophy T.F. Shih; David Silk; Anna Conway; Carla Treloar; Carolyn Murray; Charles Henderson; Janaki Amin; Phillip Read; Gregory J. Dore; Jason Grebely; Jason Grebely; Gregory J. Dore; David Silk; Nicky Bath; Carla Treloar; Andrew Milat; Adrian Dunlop; Janaki Amin; Jo Holden; Carolyn Murray; Charles Henderson; Kyle Leadbeatter; Emma Day; Nikitah Habraken; Olivia Dawson; Louisa Degenhardt; Clarke Scott; Phillip Read; Jason Grebely; Gregory J. Dore; David Silk; Heather Valerio; Shane Tillakeratne; Philippa Marks; Indika Jayasinghe; Maria Martinez; Hannah Reid; Valerie Gleeson; Jodi Van Dyk; Gerard Estivill M...; Alison D. Marshall; Stephanie Obeid; A. Wheeler; Samira Hosseini H...; Beth Catlett; Andrey Verich; Anna Conway; Amanda Erratt; Alice Wheeler; Nadine Ezard; David Reid; Carla Gorton; Jeremy Hayllar; Thao Lam; Adrian Dunlop; Prasun Datta; Alex Wade; Sally Spruce; Vicky Cock; Mark Cornwell; Krista Zohrab; Michael Christmass; Craig Connelly; Angela Cooper; Mark Montebello; Robert Cherry; Julie Dyer; Shikha Arawal; Elke Press; Nadine Horasak; Rhondda Lewis; Astrid Carthew; Daniel Morris; Kathy Donohue; Kathy Griffiths; Jason Dalla Lana; Sue Shin; Connie Graf; Adele Hampson; Siyu Qian; Danielle Brown; Amber Lautier; Cate Curran; Carina Burns; Ravina Raidu; Kylie Stolzenhein; Wanda Brabender; Kelly Somes; Nargis Abram; Rick Turne; Stuart Larter; Fiona Goodberg; Jennifer Luksza; Michelle Hall; Susan Hazelwood; Charlotte Ismay; Krista Zohrab; Belinda McClurg; Cherie Mincham; Kali Barlow; Anita Hoskins; Kate Salisbury; Julie Markham; Jacky Talmet; Sandy Dunn; Amanda Mitchell; Andrew McKinnon; Fionnualh Smyth; Lisa Snell; Elizabeth Laing; Martin Clark; Justin Dorigo; Louise Carman; Brent Fergusson; Bonny Puszka; Gai Duncan; Fiona Baker; Jayde Walsh; Leeann Walsh; Sara Adey; Rodd Hinton; Melanie Joyce; Cheryl Woods; Alain Jenart; Hope Everingham; Louisa Jansen; Lucy Pepolim; Kathy Clark; Lyn Murphy; Joel Iliffe
• Keywords: Hepatitis C

Objectives: There is limited research on health-related quality of life (HRQoL) among people who inject drugs (PWID).We evaluated the HRQoL and associated factors a cohort PWID in Australia. Methods: Participants were enrolled an observational study (the ETHOS Engage Study) May 2018 -September 2019 (Wave 1) November -June 2021 2).Participants completed EuroQol five-dimension five-level (EQ-5D-5L) survey at enrolment.Two-part models used to assess association clinical socioeconomic characteristics with EQ-5D-5L scores.Results: Among 2,395 participants (median age, 43 years; 66% male), 65% reported injecting drug use past month, 20% had current HCV infection, 68% no/mild liver fibrosis (F0/F1).Overall, mean EQ-VAS scores 0.78 57, respectively.In adjusted analysis, significantly lower include older ages, female (marginal effect= -0.03, P=0.014), being homeless -0.04, P=0.040), polysubstance -0.05, P<0.001).Factors higher Aboriginal/Torres Strait Islander 0.03, P=0.021) recent 12 months.Current infection stage not reduced participants.Conclusions: experienced compared general population.Further needed understand this population facilitate development multifaceted care for beyond cure inform health economic analyses identifying optimal strategies PWID.