Any reduction in maternal kidney mass makes a difference during pregnancy in gestational and fetal outcome

• DOI: 10.1016/j.kint.2023.12.018
• Publication Date: 2024-01-29T17:13:26Z
• Authors: Giorgina Barbara ...; Rossella Attini; Massimo Torreggiani; Antoine Chatrenet; Ana Maria Manzione; Bianca Masturzo; Viola Casula; Elisa Longhitano; Eleonora Dalmasso; Luigi Biancone; Antonello Pani; Gianfranca Cabiddu
• Keywords: Quartile

Little is known about the effect tubulointerstitial nephropathies have in modulating maternal-fetal outcomes pregnancy. Therefore, we analyzed main of pregnancy these women to gain a better understanding role reduction maternal kidney mass. From Torino Cagliari Observational Study (TOCOS) cohort, selected 529 patients with diagnosis disease and focused on 421 chronic (CKD) stage 1, without hypertension but proteinuria less than 0.5 g/day at referral. cohort 2969 singleton deliveries from low-risk pregnancies followed same settings propensity score matched control 842 match 2:1 for age, parity, body mass index, ethnicity, origin. Time delivery was significantly shorter study 38.0 (Quartile 1-Quartile 3: 37.0-39.0) versus 39.0 (Q1-Q3 38.0-40.0) weeks, respect controls. Incidence 37 gestational weeks increased controls (7.4%) previous acute pyelonephritis (10.8%), other diseases (9.7%) highest single (31.1%). Similarly, neonatal birthweight progressively decreased (3260 g [Q1-Q3: 2980- 3530]), (3090 2868- 3405], (3110 2840-3417]), solitary (2910 2480-3240]). Risk developing preeclampsia higher CKD (3.6% vs 1.7% controls). Thus, even small functional mass, such as pyelonephritic scar, associated duration an risk preterm delivery. The proportional extent parenchymal cases kidney.