Retrospective analysis of veno-occlusive disease/sinusoidal obstruction syndrome in paediatric patients undergoing hematopoietic cell transplantation -a multicentre study

• DOI: 10.1016/j.lana.2024.100728
• Publication Date: 2024-04-06T11:21:54Z
• Authors: Dristhi Ragoonanan; Hisham Abdel-Azim; Aditya Sharma; Saleh Bhar; Jennifer McArthur; Renee Madden; April Rahrig; Rajinder Bajwa; Jian Wang; Victoria Sun; Mariah Wright; Rebekah Lassiter; Basirat Shoberu; Jitesh Kawedia; Sajad Jawad Khazal; Kris Michael Mahadeo
• Keywords: Hepatic veno-occlusive disease; Pulmonary Veno-Occlusive Disease

Sinusoidal obstruction syndrome is a potentially fatal complication following hematopoietic cell transplantation, high-intensity chemotherapies and increasingly seen with calicheamicin based leukemia therapies. Paediatric specific European Society for Blood Marrow Transplantation (pEBMT) diagnostic criteria have demonstrated benefit in single center studies compared to historic criteria. Yet, the extent which they been universally implemented remains unclear.