Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China

• DOI: 10.1016/j.lanwpc.2021.100362
• Publication Date: 2022-01-01T18:08:36Z
• Authors: Zheng Zhao; Canjun Zheng; Hongchao Qi; Yue Chen; Michael P. Ward; Fengfeng Liu; Jie Hong; Qing Su; Jiaqi Huang; Xi Chen; Jiaxu Le; Xiuliang Liu; Minrui Ren; Jianbo Ba; Zhijie Zhang; Zhaorui Chang; Zhongjie Li
• Keywords: Hand-foot-and-mouth disease

BackgroundIn early 2020, non-pharmaceutical interventions (NPIs) were implemented in China to reduce and contain the coronavirus disease 2019 (COVID-19) transmission. These NPIs might have also reduced incidence of hand, foot, mouth (HFMD).MethodsThe weekly numbers HFMD cases meteorological factors 31 provincial capital cities municipalities mainland obtained from Chinese Center for Disease Control Prevention (CCDC) National Meteorological Information 2016 2020. The NPI data collected local CDCs. rate ratios (IRRs) calculated entire year January–July 2020 August–December expected case estimated using seasonal autoregressive integrated moving average models. relationships between kindergarten closures quantified a generalized additive model. associations all pooled multivariate meta-regression model.FindingsStringent widely COVID-19 control January July IRRs less than 1 cities, 0·1 23 cities. Overall, proportion by 52·9% (95% CI: 49·3−55·5%) after implementation this effect was generally consistent across subgroups.InterpretationThe decrease strongly associated with COVID-19. epidemic peaks either absent or delayed, final size reduced. Kindergarten closure is an intervention prevent outbreaks.FundingThis research supported Natural Science Foundation (81973102 & 81773487), Public Health Talents Training Program Shanghai Municipality (GWV-10.2-XD21), New Three-year Action Plan (GWV-10.1-XK16), Major Project Scientific Technical Winter Olympics Key Research Development (2021YFF0306000), 13th Five-Year Technology Infectious Diseases (2018ZX10725-509) projects PLA logistics (BHJ17J013).