Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis

• DOI: 10.1016/j.lfs.2018.02.035
• Publication Date: 2018-02-26T17:59:29Z
• Authors: Yanqiu Gong; Wenchen Pu; Hongyu Jin; Pei Yang; Hao Zeng; Yuqi Wang; Fuwen Pang; Xuelei Ma
• Keywords: Adult; Male; Proteomics; China; 0303 health sciences; Gene Expression Profiling; Nose Neoplasms; Cytarabine; Antineoplastic Agents; Middle Aged; Prognosis; Mass Spectrometry; 3. Good health; Gene Expression Regulation, Neoplastic; Lymphoma, Extranodal NK-T-Cell; 03 medical and health sciences; Ethmoid Sinus; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Humans; Female; Neoplasm Metastasis; Cerebrospinal Fluid

Extranodal natural killer cell/T-cell lymphoma of nasal-type (NKTCL) is an aggressive human lymphoma, but its predicted biomarkers after chemotherapy are less known. The aim of this study is to find some potential predicted biomarkers in cerebrospinal fluid (CSF) of NKTCL patients with ethmoidal sinus metastasis (NESM).The CSF samples were obtained from NKTCL patients with NESM before and after chemotherapy from Cancer Center of West China Hospital. Comparative proteomic profiling using label-free method was performed to characterize the fold change of proteins in NESM patients.In this study, 102 proteins with <1% false discovery rate in CSF of NKTCL with NESM patients were quantified. Furthermore, significantly reduced IGFBP2, SERP1NC1, AMBP and GPX3, as well as dramatically increased CPE levels were observed in the CSF of NKTCL patients after cytarabine chemotherapy.IGFBP2, SERP1NC1, AMBP, GPX3 and CPE together or alone have a potential to be predicted indicators of NKTCL with NESM in response to chemotherapy.