Adipocyte-hepatocyte crosstalk in cellular models of obesity: Role of soluble factors

• DOI: 10.1016/j.lfs.2023.121464
• Publication Date: 2023-01-31T03:14:43Z
• Authors: Francesca Baldini; Farah Diab; Nadia Serale; Lama Zeaiter; Piero Portincasa; Alberto Diaspro; Laura Vergani
• Keywords: Steatosis; Crosstalk

Hepatic steatosis is often a consequence of obesity. Adipose tissue an important endocrine regulator metabolic homeostasis in the body. In obesity, adipocytes become hypertrophic and develop inflammatory phenotype, altering panel secreted adipokines. Moreover, excess fatty acids are, part, released by delivered to liver. These multiple pathways adipose-liver crosstalk contribute development progression liver disease: TNFα induces hepatocyte dysfunction, circulating promotes hepatic inflammation, whilst adipokines mediate exacerbate injury. this study, we investigated vitro effects mechanisms between hepatocytes, as function different adipocyte status (mature vs hypertrophic) being mediated soluble factors. We employed conditioned medium method test how mature distinctively affect liver, leading dysfunction. The media collected from were characterized high triglyceride content led lipid accumulation fat-dependent dysfunction hepatocytes. present findings seem suggest that, addition triglycerides, other mediators, cytokines, are influence cells. Understanding precise factors involved pathogenesis pathophysiology NAFLD obesity will provide insights into responsible for complications paving way new possible approaches.