Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 Apc/+ mice

• DOI: 10.1016/j.lssr.2024.03.005
• Publication Date: 2024-03-30T16:44:05Z
• Authors: Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi
• Keywords: Radiobiology; Space Radiation

Explorations of the Moon and Mars are planned as future manned space missions, during which humans will be exposed to both radiation microgravity. We do not, however, know health effects for such combined exposures. In a ground-based experiment, we evaluated simulated microgravity on tumorigenesis by performing X-irradiation tail suspension in C3B6F1 ApcMin/+ mice, well-established model intestinal tumorigenesis. Mice were irradiated at 2 weeks age underwent 3 or 11 using special device that avoids damage tail. The treatment significantly reduced thymus weight after but not weeks, suggesting transient stress response. combination irradiation increased number small tumors less than mm diameter compared with either alone. also fraction malignant among all radiation-only treatment. Thus, mouse is useful assessing cancer risk environment, accelerates tumor progression when exposure.