Lung cancer in never smokers: Distinct population-based patterns by age, sex, and race/ethnicity

• DOI: 10.1016/j.lungcan.2022.10.009
• Publication Date: 2022-10-30T05:00:59Z
• Authors: Paulo S. Pinheiro; Karen E. Callahan; Heidy N. Medina; Tulay Koru-Sengul; Erin N. Kobetz; Scarlett Lin Gomez; Gilberto de Lima ...
• Keywords: Male; Lung Neoplasms; Incidence; Smoking; Hispanic or Latino; United States; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Ethnicity; Humans; Female

Epidemiological patterns for lung cancer among never smokers (LCNS) are largely unknown, even though LCNS cases comprise 15% of cancers. Past studies were based on epidemiologic or health system cohorts, and not fully representative the underlying population. The objective was to analyze rates (and trends) by sex, age group, race ethnicity all-inclusive truly population-based sources.Individual-level data from 2014 2018 smoking status microscopically-confirmed Florida's registry combined with population denominators adjusted NHIS prevalence compute incidence rate ratios. Incidence proportional mortality ranked against other Joinpoint regression analyses examined trends.Proportions ranged 9% White men 83% Chinese women. Overall, 13% (IRR 1.13, 95%CI 1.08-1.17) more common than women, but variation occurred female exceeding male in younger ages. Age-adjusted per 100,000 highest Asian/Pacific Islander (API) women (15.3 13.5, respectively) Black populations (14.6, 12.9), intermediate (13.2, 11.8) lowest Hispanic (12.1, 10.6). Among API second leading cause death, surpassed only breast cancer. trends stable over time.LCNS is 11th most frequently occurring 8th differences race/ethnicity small, within a range population's rates. Surprisingly, have mortality. As decreases US, will inevitably increase, warranting inquiry into risk factors across lifespan.