pH-shifting formation of goat milk casein nanoparticles from insoluble peptide aggregates and encapsulation of curcumin for enhanced dispersibility and bioactivity

• DOI: 10.1016/j.lwt.2021.112753
• Publication Date: 2021-11-03T02:06:52Z
• Authors: Xiaojing Du; Huijuan Jing; Li Wang; Xin Huang; Ling Mo; Xinpeng Bai; Hongxin Wang
• Keywords: Proteolysis

The insoluble peptide aggregates formed by proteolysis are usually discarded food industries, which results in significant wastage of resources and burden on the related industries. In present study, during enzymatic hydrolysis goat milk casein protein (GCA) were used to prepare nanoparticles (GCP) using a controlled pH-shifting treatment. Next, hydrophobic curcumin (Cur) was embedded GCP core, nano-scale stable hydrophilic particles (GCP-Cur) successfully prepared. XRD FT-TR spectroscopy showed that Cur encapsulated an amorphous form, loading does not cause conformational changes. morphological also verified successful design GCP-Cur nanoparticles. Furthermore, significantly improved water solubility, storage stability, vitro bioaccessibility, antioxidant activity Cur. Moreover, anti-gastric digestion properties could control effective release from composite into intestine, can thus be as potential delivery carrier for biologically activity. This research provides theoretical technical guidance development high-value application these low-value byproducts.