Tenascin-C targeting strategies in cancer

• DOI: 10.1016/j.matbio.2024.04.002
• Publication Date: 2024-04-18T16:16:23Z
• Authors: Sayda Dhaouadi; Balkiss Bouhaoual...; Gertraud Orend
• Keywords: Tenascin C; Matricellular protein; Tenascin

Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.