Strategies for organic nanoparticles delivering CRISPR/Cas9 for cancer therapy: Challenges and breakthroughs

• DOI: 10.1016/j.matdes.2024.113097
• Publication Date: 2024-06-17T23:22:04Z
• Authors: Tianqi Zhang; Jing Ding; Qianyu Lv; Mengxin Zhao; Yiran Liu; Qi Wang; Youqi Chen; Haoran Zhao; Hui Ren; Wei Jiang; Ling Zhang; Baofeng Guo
• Keywords: Nanocarriers

The recent years have witnessed the rapid advancement of clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9)-mediated gene editing in cancer therapy. success therapy relies heavily on development safe and effective delivery vectors. We focus organic nanocarriers because their flexible customizability, which permits them to accomplish excellent efficiency performance. In this review, pharmacokinetic behavior CRISPR/Cas9 serves as a guide outline strategies for improving bioavailability through physical, chemical, biological means. Furthermore, potential simultaneous therapeutic agents tools is highlighted. Finally, we discuss future directions nanosystems, paving way construction systems.