Sol–gel synthesis of collagen-inspired peptide hydrogel

• DOI: 10.1016/j.mattod.2017.02.001
• Publication Date: 2017-03-21T02:15:50Z
• Authors: Cécile Echalier; Said Jebors; Guillaume Laconde; Luc Brunel; Pascal Verdié; Léa Causse; Audrey Bethry; Baptiste Legrand; Hélène Van Den Be...; Xavier Garric; Danièle Noël; Jean Martinez; Ahmad Mehdi; Gilles Subra
• Keywords: Micropatterning; Biocompatible material; Gelatin

Conceiving biomaterials able to mimic the specific environments of extracellular matrices are a prerequisite for tissue engineering applications. Numerous types polymers (PEG, PLA, etc.) have been used design biocompatible scaffolds, but they still less efficient than natural biopolymers such as collagen extracts. Chemically modified and loaded with different bioactive factors, afford an environment favourable cell proliferation differentiation. Unfortunately, present several drawbacks, weak batch-to-batch reproducibility, potential immunogenicity high cost production. Herein we propose fully synthetic covalent hydrogel obtained by sol–gel polymerization silylated peptide. We selected short low molecular building-block derived from consensus sequence [Pro-Hyp-Gly]. Interestingly, process occurs in physiological buffer, enabling embedment stem cells. This collagen-inspired provides cell-friendly comparable substrates, demonstrating its potency biomimetic scaffold.