Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008–2017)

• DOI: 10.1016/j.mayocp.2020.06.056
• Publication Date: 2021-01-07T20:05:02Z
• Authors: Juan M. Pericàs; Juan Ambrosioni; Patricia Muñoz; Arístides de Alarcón; Martha Kestler; Amaia Mari-Hualde; Asunción Moreno; Miguel Á. Goenaga; M. Carmen Fariñas; Regino Rodríguez-...; Guillermo Ojeda-B...; Juan Gálvez-Acebal; Carmen Hidalgo-Te...; Mariam Noureddine; José M. Miró; Fernando Fernánde...; Mariam Noureddine; Gabriel Rosas; Javier de la Torr...; Roberto Blanco; María Victoria Boado; Marta Campaña Lázaro; Alejandro Crespo; Josune Goikoetxea; José Ramón Iruret...; Josu Irurzun Zuaz...; Leire López-Soria; Miguel Montejo; Javier Nieto; David Rodrigo; Regino Rodríguez; Yolanda Vitoria; Roberto Voces; Ma Victoria Garcí...; Radka Ivanova Geo...; Guillermo Ojeda; Isabel Rodríguez ...; Josefa Ruiz Morales; Ana María Cuende; Tomás Echeverría; Ana Fuerte; Eduardo Gaminde; Miguel Ángel Goenaga; Pedro Idígoras; José Antonio Irib...; Alberto Izaguirre...; Xabier Kortajaren...; Carlos Reviejo; Rafael Carrasco; Vicente Climent; Patricio Llamas; Esperanza Merino; Joaquín Plazas; Sergio Reus; Nemesio Álvarez; José María Bravo-...; Laura Castelo; José Cuenca; Pedro Llinares; Enrique Miguez Rey; María Rodríguez Mayo; Efrén Sánchez; Dolores Sousa Reg...; Francisco Javier ...; Ma del Mar Alonso; Beatriz Castro; Dácil García Rosado; Ma del Carmen Durán; Ma Antonia Miguel...; Juan Lacalzada; Ibrahim Nassar; Antonio Plata Ciezar; José Ma Reguera I...; Víctor Asensi Álv...; Carlos Costas; Jesús de la Hera; Jonnathan Fernánd...; Lisardo Iglesias ...; Víctor León Arguero; José López Menéndez; Pilar Mencia Bajo; Carlos Morales; Alfonso Moreno To...; Carmen Palomo; Begoña Paya Martínez; Ángeles Rodríguez...; Raquel Rodríguez ...; Mauricio Telenti ...; Manuel Almela; Juan Ambrosioni; Manuel Azqueta; Mercè Brunet; Marta Bodro; Ramón Cartañá; Carlos Falces; Guillermina Fita; David Fuster; Cristina García d...; Delia García-Pares; Marta Hernández-M...; Jaume Llopis Pérez; Francesc Marco; José M. Miró; Asunción Moreno; David Nicolás; Salvador Ninot; Eduardo Quintana; Carlos Paré; Daniel Pereda; Juan M. Pericás; José L. Pomar; José Ramírez; Irene Rovira; Elena Sandoval; Marta Sitges; Dolors Soy; Adrián Téllez; José M. Tolosana; Bárbara Vidal; Jordi Vila; Iván Adán; Javier Bermejo; Emilio Bouza; Daniel Celemín; Gregorio Cuerpo C...; Antonia Delgado M...; Ana García Mansilla; Ma Eugenia García...; Víctor González R...; Martha Kestler He...; Amaia Mari Hualde; Mercedes Marín; Manuel Martínez-S...; Patricia Muñoz; Cristina Rincón; Hugo Rodríguez-Ab...; Marta Rodríguez-C...; Blanca Pinilla; Ángel Pinto; Maricela Valerio; Pilar Vázquez; Eduardo Verde Moreno; Isabel Antorrena; Belén Loeches; Alejandro Martín ...; Mar Moreno; Ulises Ramírez; Verónica Rial Bastón; María Romero; Araceli Saldaña; Jesús Agüero Balbín; Carlos Armiñanzas...; Ana Arnaiz; Francisco Arnaiz ...; Manuel Cobo Belau...; María Carmen Fariñas; Concepción Fariña...; Rubén Gómez Izqui...; Iván García; Claudia González ...; Manuel Gutiérrez-...; José Gutiérrez Díez; Marcos Pajarón; José Antonio Parra; Ramón Teira; Jesús Zarauza; Jorge Calderón Parra; Marta Cobo; Fernando Domínguez; Alberto Fortaleza; Pablo García Pavía; Jesús González; Ana Fernández Cruz; Elena Múñez; Antonio Ramos; Isabel Sánchez Ro...; Tomasa Centella; José Manuel Hermida; José Luis Moya; Pilar Martín-Dávila; Enrique Navas; Enrique Oliva; Alejandro del Río; Jorge Rodríguez-R...; Soledad Ruiz; Carmen Hidalgo Te...; Manuel Almendro D...; Omar Araji; José Miguel Barquero; Román Calvo Jambrina; Marina de Cueto; Juan Gálvez Acebal; Irene Méndez; Isabel Morales; Luis Eduardo Lópe...; Arístides de Alarcón; Emilio García; Juan Luis Haro; José Antonio Lepe; Francisco López; Rafael Luque; Luis Javier Alonso; Pedro Azcárate; José Manuel Azcon...; José Ramón Blanco; Antonio Cabrera V...; Lara García-Álvarez; José Antonio Oteo; Mercedes Sanz; Natividad de Benito; Mercé Gurguí; Cristina Pacho; Roser Pericas; Guillem Pons; M. Álvarez; A.L. Fernández; Amparo Martínez; A. Prieto; Benito Regueiro; E. Tijeira; Marino Vega; Andrés Canut Blasco; José Cordo Mollar; Juan Carlos Gainz...; Oscar García Uriarte; Alejandro Martín ...; Zuriñe Ortiz de Z...; José Antonio Urtu...; García-Domínguez ...; Sánchez-Porto Ant...; José Ma Arribas Leal; Elisa García Vázquez; Alicia Hernández ...; Ana Blázquez; Gonzalo de la Mor...; Ángel Alonso; Javier Aramburu; Felicitas Elena C...; Anai Moreno Rodrí...; Paola Tarabini-Ca...; Eva Heredero Gálvez; Carolina Maicas B...; José Largo Pau; Ma Antonia Sepúlveda; Pilar Toledano Si...; Sadaf Zafar Iqbal...; Eva Cascales Alcolea; Ivan Keituqwa Yañez; Julián Navarro Ma...; Ana Peláez Ballesta; Eduardo Moreno Es...; Alejandro Peña Monje; Valme Sánchez Cab...; David Vinuesa García; María Arrizabalag...; Carmen Cifuentes ...; Juana Núñez Morcillo; Ma Cruz Pérez Seco; Aroa Villoslada G...; Carmen Aured Guallar; Nuria Fernández Abad; Pilar García Mangas; Marta Matamala Adell; Ma Pilar Palacián...; Juan Carlos Porres; Begoña Alcaraz Vidal; Nazaret Cobos Tri...; María Jesús Del A...; José Antonio Gine...; Roberto Jiménez S...; Amaya Jimeno Almazán; Alejandro Ortín F...; Monserrat Viqueir...; Pere Pericás Ramis; Ma Ángels Ribas B...; Enrique Ruiz de G...; Laura Vidal Bonet; Ma Carmen Bellón ...; Elena Escribano G...; Antonia Tercero M...; Juan Carlos Segur...; Cristina Badía; Lucía Boix Palop; Mariona Xercavins; Sónia Ibars. Eloy...; Ibalia Horcajada ...; Irene Menduiña Ga...; Isabel de Miguel ...; Elena Pisos Álamo
• Keywords: Aged, 80 and over; Male; Colonoscopy; Endocarditis, Bacterial; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Enterococcus faecalis; Prevalence; Humans; Female; Colorectal Neoplasms; Gram-Positive Bacterial Infections; Aged; Retrospective Studies

To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection.Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients.One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus.Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.