Identification of Proteome-Based Immune Subtypes of Early Hepatocellular Carcinoma and Analysis of Potential Metabolic Drivers

• DOI: 10.1016/j.mcpro.2023.100686
• Publication Date: 2023-11-25T05:55:00Z
• Authors: Lihong Diao; Mengqi He; Binsheng Xu; Lanhui Chen; Ze Wang; Yuting Yang; Simin Xia; Shengwei Hu; Shuzhen Guo; Dong Li
• Keywords: Proteome

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, ranking fourth in frequency. The relationship between metabolic reprogramming and immune infiltration has been identified as having crucial impact on HCC progression. However, deeper understanding the interplay system metabolism microenvironment required. In this study, we used proteomic dataset to identify three subtypes (IM1-IM3) HCC, each which distinctive clinical, immune, characteristics. Among these subtypes, IM3 was found have poorest prognosis, with highest levels T-cell exhaustion. Furthermore, showed elevated glycolysis reduced bile acid metabolism, strongly correlated CD8 T cell exhaustion regulatory accumulation. Our study presents stratification revealing possible link cells may be viable therapeutic strategy improve immunotherapy.