Chemical Proteomics Reveals Nε-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization

• DOI: 10.1016/j.mcpro.2024.100730
• Publication Date: 2024-02-02T16:36:56Z
• Authors: Yaxin Xu; Ke Ding; Tao Peng
• Keywords: Septin

Vibrio species, the Gram-negative bacterial pathogens causing cholera and sepsis, produce multiple secreted virulence factors for infection pathogenesis. Among these is multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin that releases several critical effector domains with distinct functions inside eukaryotic host cells. One such domain, Rho inactivation domain (RID), has been discovered to catalyze long-chain N