A computational analysis of a novel therapeutic approach combining an advanced medicinal therapeutic device and a fracture fixation assembly for the treatment of osteoporotic fractures: Effects of physiological loading, interface conditions, and fracture fixation materials

• DOI: 10.1016/j.medengphy.2023.103967
• Publication Date: 2023-03-12T06:36:46Z
• Authors: Subrata Mondal; David B. MacManus; Amedeo Franco Bon...; Carmelo De Maria; Kenny Dalgarno; Maria Chatzinikol...; Aurora De Acutis; Giovanni Vozzi; Sonia Fiorilli; Chiara Vitale-Bro...; Nicholas Dunne
• Keywords: Stress shielding; Femoral fracture; Stair climbing

The occurrence of periprosthetic femoral fractures (PFF) has increased in people with osteoporosis due to decreased bone density, poor quality, and stress shielding from prosthetic implants. PFF treatment the elderly is a genuine concern for orthopaedic surgeons as no effective solution currently exists. Therefore, goal this study was determine whether design novel advanced medicinal therapeutic device (AMTD) manufactured polymeric blend combination fracture fixation plate femur capable withstanding physiological loads without failure during regenerative process. This achieved by developing finite element (FE) model AMTD together assembly, an implanted stem. response both normal osteoporotic investigated implementing their respective material properties model. Physiological loading simulating peak load standing, walking, stair climbing investigated. results showed that assembly prime bearing component configuration devices. Within screws were found have highest stresses all conditions. Whereas within significantly below maximum yield strength device's material. Furthermore, also performance different materials Ti-6Al-4V be optimal choice those included study.