Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study

• DOI: 10.1016/j.metabol.2021.154911
• Publication Date: 2021-10-13T06:31:30Z
• Authors: Eunice Xiang-Xuan...; Jonathan Wei-Jie Lee; Nur Halisah Jumat; Wah-Kheong Chan; Sombat Treepraser...; George Boon-Bee Goh; Jian-Gao Fan; Myeong Jun Song; Phunchai Charatch...; Ajay Duseja; Kento Imajo; Atsushi Nakajima; Yosuke Seki; Kazunori Kasama; Satoru Kakizaki; Laurentius A. Les...; Kenneth I. Zheng; Ming-Hua Zheng; Calvin J. Koh; Khek-Yu Ho; Khean-Lee Goh; Vincent Wai-Sun Wong; Yock-Young Dan
• Keywords: Steatohepatitis

A significant proportion of the non-alcoholic fatty liver disease (NAFLD) population is non-obese. Prior studies reporting severity NAFLD amongst non-obese patients were heterogenous. Our study, using data from largest biopsy-proven international registry within Asia, aims to characterize demographic, metabolic and histological differences between obese patients.1812 across nine countries in Asia assessed 2006 2019 pooled into a curated clinical registry. Demographic, evaluated. The performance Fibrosis-4 index for fibrosis (FIB-4) score (NFS) identify advanced varying obesity subgroups was compared. random forest analysis performed novel predictors steatohepatitis patients.One-fifth (21.6%) Non-obese had lower proportions NASH (50.5% vs 56.5%, p = 0.033) (14.0% 18.7%, 0.033). Metabolic syndrome individuals associated with (OR 1.59, 95% CI 1.01-2.54, 0.047) 1.88, 0.99-3.54, 0.051). FIB-4 better than NFS (AUROC 81.5% 73.7%, < 0.001) when classifying F2-4 patients. Haemoglobin, GGT, waist circumference cholesterol are additional variables found on useful identifying disease.A substantial has or fibrosis. FIB-4, compared identifies disease. Serum cholesterol, haemoglobin circumference, which neither components nor important biomarkers