In vitro evaluation of the antibacterial activities of radezolid and linezolid for Streptococcus agalactiae

• DOI: 10.1016/j.micpath.2019.103866
• Publication Date: 2019-11-09T16:12:20Z
• Authors: Jin-xin Zheng; Zhong Chen; Zhi-chao Xu; Jun-wen Chen; Guang-jian Xu; Xiang Sun; Zhi-jian Yu; Di Qu
• Keywords: Linezolid; 23S ribosomal RNA; Agar dilution

This study aims to evaluate the antimicrobial activities of linezolid and radezolid against Streptococcus agalactiae in vitro compared for genetic resistance factors.Nonduplicate S. clinical isolates (n = 136) were collected minimal inhibitory concentrations antimicrobials determined by agar dilution methodology. The linezolid-resistant mechanism linezolid-non-susceptible that induced pressure analyzed PCR sequence alignment. Antimicrobial distinctions between further investigated vitro.Our data indicated 17 (13%) 136 not susceptible linezolid. For individual isolates, including linezolid-nonsusceptible with 23S rRNA V domain mutations, MIC90 values generally one-half one-quarter values. Radezolid MICs remained low relative among but exhibited synchronous increases increasing copy numbers mutations. Overall, 13 optrA-carrying found this their all sensitive both radezolid. Clinical high showed clonality clustering type (ST)10.Radezolid exhibits stronger potency than there is a concerning presence samples.