Synthesis of urea-functionalized magnetic porous organic polymers Fe3O4@PDA@UPOPs for rapid extraction of fluoroquinolones in food samples

• DOI: 10.1016/j.micromeso.2021.111269
• Publication Date: 2021-06-30T06:25:53Z
• Authors: Yin-Long Li; Xue-Mei Nie; Xiu-Juan Wang; Feng Zhang; Min-Li Yang; Wei Guo; Feng-Ming Chen; Tong Liu; Mu-Yi He
• Keywords: Solid phase extraction

Abstract It is of great interest in the development of reliable strategies for efficient adsorption and enrichment of drug residues in sample pretreatment. In this paper, urea-based porous organic polymers (UPOPs) were synthesized by the atom economic polymerization reaction of 1,4-phenylene diisocyanate (PPDI) and 1,3,5-tris(4-aminophenyl)benzene (TAPB) under mild conditions. Inspired by the versatility of polydopamine (PDA) coating, the UPOPs were successfully decorated on PDA coated-magnetic nanoparticles (Fe3O4@PDA) via in situ catalyst-free polymerization to afford urea-functionalized porous organic polymers (Fe3O4@PDA@UPOPs). The synthesized adsorbents exhibited good stability, high hydrophicility, microporous and mesoporous structure. The applicability of Fe3O4@PDA@UPOPs was evaluated as effective adsorbents for the magnetic solid-phase extraction (MSPE) of fluoroquinolones (FQs) from food samples (milk, egg and chicken muscle). Combined with high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis, the optimized method featured low adsorbents dosage (2 mg) and rapid extraction (2 min), which provided a wide linear range (0.1–200.0 ng/g, r ≥ 0.9991) and high sensitivity (LODs: 0.04–0.1 ng/g) for FQs determination. Furthermore, controllable magnetism enable the adsorbents could be easily recovered by external magnet and reused at least eight extraction cycles without decreasing the adsorption performance.