HLA class I and class II haplotypes in admixed families from several regions of Mexico

• DOI: 10.1016/j.molimm.2007.07.042
• Publication Date: 2007-09-28T17:16:46Z
• Authors: Rodrigo Barquera; Joaquín Zúñiga; Raquel Hernández-...; Victor Acuña-Alonzo; Karla Montoya-Gama; Juan Moscoso; Diana Torres-García; Claudia García-Salas; Beatriz Silva; David Cruz-Robles; Antonio Arnaiz-Vi...; Gilberto Vargas-A...; Julio Granados
• Keywords: Male; 0301 basic medicine; 03 medical and health sciences; Genetics, Population; Haplotypes; HLA Antigens; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humans; Female; Mexico; Linkage Disequilibrium

We studied HLA class I and class II alleles in 191 Mexican families (381 non-related individuals) to directly obtain the HLA-A/B/DRB1/DQB1 haplotypes and their linkage disequilibrium (LD). The most frequent HLA haplotypes observed were: A*02-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*04-DQB1*0302, A*68-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*08-DQB1*04, A*33-B*1402-DRB1*01-DQB1*05, and A*24-B*35-DRB1*04-DQB1*0302. The four most common haplotypes found by our study involve those previously reported in Amerindian populations. LD analysis of HLA-A-B and HLA-B-DRB1 loci showed significant associations between A29(19)-B44(12), A33(19)-B65(14), A1-B8, A26(19)-B44(12), A24(9)-B61(40), B65(14)-DR1, B8-DR17(3), B44(12)-DR7, B7-DR15(2), and B39(16)-DR4. Also, all DRB1-DQB1 associations showed significant LD values. Admixture estimations using a trihybrid model showed that Mexicans from the State of Sinaloa (Northern Mexico) have a greater proportion of European genetic component compared with Mexicans from the Central area of Mexico, who have a greater percentage of Amerindian genes. Our results are important for future comparative genetic studies of different Mexican ethnic groups with special relevance to disease association and transplantation studies.