Synthesis, investigation of the new derivatives of dihydropyrimidines and determination of their biological activity

• DOI: 10.1016/j.molstruc.2017.03.084
• Publication Date: 2017-03-25T19:46:55Z
• Authors: A.M. Maharramov; M.A. Ramazanov; G.A. Guliyeva; A.E. Huseynzada; U.A. Hasanova; N.G. Shikhaliyev; G.M. Eyvazova; S.F. Hajiyeva; I.G. Mamedov; M.M. Aghayev
• Keywords: Diastereomer; Proton NMR

Abstract We reported of synthesis and investigation of the new biologically active derivatives of dihydropyrimidines 2 and 3. The investigation of structures of compounds by various experiments of NMR spectroscopy revealed the splitting of the signals to doublets and multiplets that confirms the presence of diastereomers in solution of compound 2 and the presence of diastereomers and tautomers in solution of compound 3. The individual diastereomer of compound 3 has been isolated. Biological activity of the synthesized compounds was studied on various species of genus Aspergillus fungi.