Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

• DOI: 10.1016/j.molstruc.2020.128520
• Publication Date: 2020-05-25T20:05:25Z
• Authors: Alcives Avila-Sor...; Alejandro Y. Band...; Verónica Alvarez-...; Erick Suarez-Cont...; Rocío Nieto-Meneses; Benjamín Nogueda-...; María Elena Varga...; Francisco Díaz-Ce...; Reyna Reyes-Martínez; Simon Hernandez-O...; David Morales-Mor...
• Keywords: Benznidazole; Nifurtimox; Antiparasitic; Trypanocidal agent

Abstract A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).