Synthesis, crystal structure and antibacterial properties of 6-methyl-2-oxo-4-(quinolin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

• DOI: 10.1016/j.molstruc.2020.128581
• Publication Date: 2020-06-06T01:16:20Z
• Authors: A.E. Huseynzada; C. Jelsch; H.N. Akhundzada; S. Soudani; C. Ben Nasr; F. Doria; U.A. Hasanova; M. Freccero
• Keywords: Carboxylate; Derivative (finance); Crystal (programming language)

Abstract The synthesis and investigation of a new biologically active derivative of dihydropyrimidine are reported. The structure of the synthesized compound was investigated by X-ray single crystal diffraction method. In order to understand the molecular interactions, the Hirshfeld surface and contacts enrichment analyses were performed. The crystal packing is mainly stabilized by strong N–H⋯O hydrogen bonds and aromatic cycle stacking. Among the different types of oxygen atoms, the most electronegative had the highest propensity to form H-bonds. Biological activity of the synthesized compound was studied against E.coli, P. aeruginosa and S. aureus bacteria.