Zinc(II) niflumato complex with neocuproine: Synthesis, crystal structure, characterization and cytotoxic effects on human endometrial cell lines

• DOI: 10.1016/j.molstruc.2021.130312
• Publication Date: 2021-03-23T05:02:29Z
• Authors: Lukáš Smolko; Ivana Špaková; Zuzana Klepcová; Katarína Dubayová; Erika Samoľová; Miroslava Rabajdová; Mária Mareková
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Novel zinc niflumato complex with a composition of [Zn(neo)(nif)2] (neo = neocuproine; nif = niflumato) was prepared in crystalline form and characterized by elemental analysis and spectroscopic methods (IR, UV/VIS and fluorescence). According to the results of the single-crystal X-ray structural analysis the central Zn(II) atoms within the complex molecules are tetracoordinated by two oxygen atoms of nif ligands and two nitrogen atoms of chelate bonded neo. The cytotoxic measurements on two endometrial cell lines hTERT and 12Z indicate selectivity of the complex towards the endometriotic 12Z cell line. In addition, spectral binding studies performed on isolated DNA samples revealed higher affinity of the complex to the 12Z DNA, thus suggesting possible specific DNA sequence recognition.