Biodegradable polyurethane nanocomposites containing dexamethasone for ocular route

• DOI: 10.1016/j.msec.2010.10.019
• Publication Date: 2010-11-07T09:08:12Z
• Authors: Gisele Rodrigues ...; Armando da Silva-...; Francine Behar-Cohen; Eliane Ayres; Rodrigo L. Oréfice
• Keywords: Biodegradable polymer; Small-angle X-ray scattering

The treatment of posterior segment ocular diseases, such as uveitis, by using eye drops and oral drugs is usually not effective due to the body's natural barriers drug penetration. In this study, implants treat uveitis were synthesized incorporating dexamethasone acetate, an important type corticoid used in some into a biodegradable polyurethane containi clay nanoparticles. Biodegradable nanocomposites having poly(caprolactone) oligomers soft segments obtained delaminating particles within aqueous dispersion. was incorporated polymer dispersing it waterborne followed drying step. Nanoparticles derived from demonstrated be able tailor mechanical properties polyurethanes achieve values that can match tissues. Infrared spectra (FTIR) showed presence change microphase separation process typical polyurethanes. X-ray diffraction small angle x-ray scattering (SAXS) results explored show incorporation both acetate nanocomponents led less defined two-phase polyurethane. nanoparticles increased rate release measured vitro. Human retinal pigment epithelial cells (ARPE-19) cultured contact with nanocomposites, viability them (evaluated MTT assay after 7 days) no toxic components released containing during test.