Activated carbon fibers/poly(lactic-co-glycolic) acid composite scaffolds: Preparation and characterizations

• DOI: 10.1016/j.msec.2014.07.007
• Publication Date: 2014-07-09T08:04:21Z
• Authors: Yanni Shi; Hao Han; Haiyu Quan; Yongju Zang; Ning Wang; Guizhi Ren; Melcolm Xing; Qilin Wu
• Keywords: Tissue Engineering; Tissue Scaffolds; 02 engineering and technology; Carbon; Cell Line; Mice; Polylactic Acid-Polyglycolic Acid Copolymer; Spectroscopy, Fourier Transform Infrared; Microscopy, Electron, Scanning; Animals; Adsorption; Lactic Acid; 0210 nano-technology; Polyglycolic Acid

The present work is a first trial to introduce activated carbon fibers (ACF) with high adsorption capacity into poly(lactic-co-glycolic) acid (PLGA), resulting in a novel kind of scaffolds for tissue engineering applications. ACF, prepared via high-temperature processing of carbon fibers, are considered to possess bioactivity and biocompatibility. The ACF/PLGA composite scaffolds are prepared by solvent casting/particulate leaching method. Increments in both pore quantity and quality over the surface of ACF as well as a robust combination between ACF and PLGA matrix are observed via scanning electron microscopy (SEM). The high adsorption capacity of ACF is confirmed by methylene blue solution absorbency test. The surfaces of ACF are affiliated with many hydrophilic groups and characterized by Fourier transform infrared spectroscopy. Furthermore, the SEM images show that cells possess a favorable spreading morphology on the ACF/PLGA scaffolds. Besides, vivo experiments are also carried out to evaluate the histocompatibility of the composite scaffolds. The results show that ACF have the potential to become one of the most promising materials in biological fields.