In vitro and in vivo comparison of binary Mg alloys and pure Mg

• DOI: 10.1016/j.msec.2015.12.064
• Publication Date: 2015-12-30T03:00:27Z
• Authors: Anastasia Myrissa; Nezha Ahmad Agha; Yiyi Lu; Elisabeth Martinelli; Johannes Eichler; Gábor Szakács; Claudia Kleinhans; Regine Willumeit-...; Ute Schäfer; Annelie-Martina W...
• Keywords: Degradation

Biodegradable materials are under investigation due to their promising properties for biomedical applications as implant material. In the present study, two binary magnesium (Mg) alloys (Mg2Ag and Mg10Gd) pure Mg (99.99%) were used in order compare degradation performance of vitro vivo conditions. analysis cell distribution viability was performed on discs Mg, Mg2Ag Mg10Gd. The results verified viable pre-osteoblast cells all three no obvious toxic effect within first weeks. rates conditions (Sprague–Dawley® rats) showed that differ especially 1st week experiments. While displayed fastest rate, vivo, Mg10Gd revealed highest rate. After four weeks immersion tests, rate significantly reduced approached values Interestingly, after 4 estimated approximate values. Our systematic experiment indicates a correlation between observations still has some limitations have be considered perform representative experiments display situation.