Loading of atorvastatin and linezolid in β-cyclodextrin–conjugated cadmium selenide/silica nanoparticles: A spectroscopic study

• DOI: 10.1016/j.msec.2016.04.034
• Publication Date: 2016-04-14T02:31:23Z
• Authors: Eva Janet Antony; Abhishek Shibu; Sivaraj Ramasamy; Mosae Selvakumar ...; Israel V.M.V. Enoch
• Keywords: Drug Carriers; Spectrophotometry, Infrared; beta-Cyclodextrins; Linezolid; Silicon Dioxide; 01 natural sciences; Dynamic Light Scattering; 0104 chemical sciences; Microscopy, Electron, Transmission; Atorvastatin; Cadmium Compounds; Fluorescence Resonance Energy Transfer; Nanoparticles; Particle Size; Selenium Compounds

The preparation of β-cyclodextrin-conjugated cadmium selenide-silica nanoparticles, the loading of two drugs viz., Atorvastatin and linezolid in the cyclodextrin cavity, and the fluorescence energy transfer between CdSe/SiO2 nanoparticles and the drugs encapsulated in the cyclodextrin cavity are reported in this paper. IR spectroscopy, X-ray diffractometry, transmission electron microscopy, and particle size analysis by light-scattering experiment were used as the tools of characterizing the size and the crystal system of the nanoparticles. The nanoparticles fall under hexagonal system. The silica-shell containing CdSe nanoparticles were functionalized by reaction with aminoethylamino-β-cyclodextrin. Fluorescence spectra of the nanoparticles in their free and drug-encapsulated forms were studied. The FÖrster distances between the encapsulated drugs and the CdSe nanoparticles are below 3nm. The change in the FÖrster resonance energy parameters under physiological conditions may aid in tracking the release of drugs from the cavity of the cyclodextrin.