Evaluation of bone loss in antibacterial coated dental implants: An experimental study in dogs

• DOI: 10.1016/j.msec.2016.07.020
• Publication Date: 2016-07-10T04:46:24Z
• Authors: Maria Godoy-Gallardo; Maria Cristina Ma...; Pablo Sevilla; José Nart; Norberto Manzanares; José M. Manero; Francisco Javier Gil; Steven K. Boyd; Daniel Rodríguez
• Keywords: Gossos; TESPSA; Surface Properties; Silver electrodeposition; Antibacterial coating; Gingiva; 610; Recobriment antibacterià; 616.3; :Enginyeria dels materials [Àrees temàtiques de la UPC]; Bacteris; Antibacterial coating, Dental implants, In vivo, Peri-implantitis, Silver electrodeposition, TESPSA; 03 medical and health sciences; Dogs; 0302 clinical medicine; Coated Materials, Biocompatible; dental implants; 617; silver electrodeposition; Periimplantitis; Animals; Bone Resorption; Perros; Gossos -- Malalties; Dental Implants; Ions; Implantes dentales; Àrees temàtiques de la UPC::Enginyeria dels materials; Implants dentals; Bacteria; Dental implants; Electrodeposició de plata; Pròtesis dentals; Recubrimiento antibacterias; Electrodeposición de plata; Anti-Bacterial Agents; 3. Good health; in vivo; Antibacterial agents; Materials biomèdics; Female; Bacterias; Biomedical materials; peri-implantitis

The aim of this study was to evaluate the in vivo effect of antibacterial modified dental implants in the first stages of peri-implantitis. Thirty dental implants were inserted in the mandibular premolar sites of 5 beagle dogs. Sites were randomly assigned to Ti (untreated implants, 10units), Ti_Ag (silver electrodeposition treatment, 10units), and Ti_TSP (silanization treatment, 10units). Coated implants were characterized by scanning electron microscopy, interferometry and X-ray photoelectron spectroscopy. Two months after implant insertion, experimental peri-implantitis was initiated by ligature placement. Ligatures were removed 2months later, and plaque formation was allowed for 2 additional months. Clinical and radiographic analyses were performed during the study. Implant-tissue samples were prepared for micro computed tomography, backscattered scanning electron microscopy, histomorphometric and histological analyses and ion release measurements. X-ray, SEM and histology images showed that vertical bone resorption in treated implants was lower than in the control group (P<0.05). This effect is likely due to the capacity of the treatments to reduce bacteria colonization on the implant surface. Histological analysis suggested an increase of peri-implant bone formation on silanized implants. However, the short post-ligature period was not enough to detect differences in clinical parameters among implant groups. Within the limits of this study, antibacterial surface treatments have a positive effect against bone resorption induced by peri-implantitis.