Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation

• DOI: 10.1016/j.msec.2019.03.091
• Publication Date: 2019-03-27T22:51:32Z
• Authors: Hao Zhu; Xiongfa Ji; Hanfeng Guan; Liming Zhao; Libo Zhao; Changyu Liu; Cong Cai; Weijing Li; Tenghui Tao; Janne Elin Reseland; Håvard Jostein Ha...; Jun Xiao
• Keywords: 0301 basic medicine; Minerals; 660; Calorimetry, Differential Scanning; Polymers; Surface Properties; Spectrometry, X-Ray Emission; Ketones; Alkaline Phosphatase; Cell Line; Polyethylene Glycols; Rats, Sprague-Dawley; Benzophenones; Mice; 03 medical and health sciences; Gene Expression Regulation; Osseointegration; Osteogenesis; Materials Testing; Cell Adhesion; Animals; Nanoparticles; Collagen

Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength PEEK can be changed meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced modify PEEK, which reinforced with different contents nanoparticles (from 1 wt% 9 wt%). Mechanical biological functions (both vitro vivo) then investigated. The highest compressive observed 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization osteogenesis related gene expression showed preferable results 3%Ta-PEEK 5%Ta-PEEK. Improved bone integration shown 5%Ta-PEEK vivo. Above all, enhanced mechanical promoted formation proved compared others groups both vivo, suggesting that addition modified osseointegration ability This composite could have clinical potential implants.