Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release

• DOI: 10.1016/j.mtbio.2023.100628
• Publication Date: 2023-04-06T16:41:22Z
• Authors: Chuan Xie; Qinqin Xiong; Yuanzhi Wei; Xin Li; Jiajun Hu; Min He; Shinan Wei; Jia Yu; Sha Cheng; Mashaal Ahmad; Yufei Liu; Sihai Luo; Xi Zeng; Jie Yu; Heng Luo
• Keywords: Polyvinylpyrrolidone; Adipate; Polybutylene terephthalate

Sustained drug release has attracted increasing interest in targeted therapy. However, existing methods of therapy suffer action time, large fluctuations the effective concentration drug, and risk side effects. Here, a biodegradable composite polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting electrospun hollow microspheres as sustained-released carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate (Erlotinib) than that PBAT. Furthermore, loaded with Erlotinib provide sustained effect, thus achieving better efficacy after direct injection erlotinib due to fact allow high tumor for longer period. Hence, this work provides potential solution clinical tissue engineering using release.