The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration

• DOI: 10.1016/j.mucimm.2023.09.006
• Publication Date: 2023-09-30T20:51:48Z
• Authors: Jesuthas Ajendra; Pedro H. Papotto; James E. Parkinson; Rebecca J. Dodd; André L. Bombeiro; Stella Pearson; Brian H.K. Chan; Julie C. Ribot; Henry J. McSorley; Tara E. Sutherland; Judith E. Allen
• Keywords: Nippostrongylus brasiliensis; Interleukin 33

The early migratory phase of pulmonary helminth infections is characterized by tissue injury leading to the release alarmin interleukin (IL)-33 and subsequent induction type 2 immune responses. We recently described a role for IL-17A, through suppression interferon (IFN)-γ, as an important inducer responses during infection with lung-migrating rodent nematode Nippostrongylus brasiliensis. Here, we aimed investigate interaction between IL-17A IL-33 lung stages N. brasiliensis infection. In this brief report, demonstrate that deficiency leads impaired expression secretion in infection, independent IFN-γ. Neutrophil-depletion experiments, which dramatically reduce injury, revealed neutrophils are primarily responsible IL-17A-dependent into airways. Taken together, our results reveal IL-17A-neutrophil-axis can drive highlighting additional pathway regulates immunity.