Marine actinobacterial mediated gold nanoparticles synthesis and their antimalarial activity

• DOI: 10.1016/j.nano.2013.02.002
• Publication Date: 2013-02-20T03:04:45Z
• Authors: L. Karthik; Gaurav Kumar; Tarun Keswani; Arindam Bhattacha...; B. Palakshi Reddy; K.V. Bhaskara Rao
• Keywords: Male; 0303 health sciences; Cell Death; Plasmodium berghei; Tumor Necrosis Factor-alpha; Metal Nanoparticles; Streptomyces; Malaria; 3. Good health; Antimalarials; Mice; 03 medical and health sciences; Liver; X-Ray Diffraction; Transforming Growth Factor beta; Animals; Seawater; Gold; Spleen

Streptomyces sp LK-3 (JF710608) mediated Gold nanoparticles (Au-N-LK3) were found within the size range of 5-50 nm. Au-N-LK3 treatment in Plasmodium berghei ANKA (PbA) infected mice delayed the parasitemia rise (~6%) compared to PbA infection on 8 days post infection. Survivability of mice increases to ~85% in Au-N-LK3 treated mice in contrast to in PbA (~50%) infected mice in 8 dpi with respect to control. During Au-N-LK3 treatment in PbA infection, histomorphological analysis revealed as such no change in spleen and liver tissue during 8 dpi. Our results confirmed up-regulation of TGF-β and down-regulation of TNF-α in tissue and serum level in PbA infected Au-N-LK3 treated mice compared to PbA infection. No significant changes were found in the hatchability of Artemia embryos upto 8 mg. The results obtained suggest that the Au-N-LK3 possess anti-malarial activity and could be considered as a potential source for anti-malarial drug development.These investigators present a method of marine actinobacteria mediated synthesis of gold nanoparticles, resulting in nanoparticles that possess anti-malarial activity and could be considered in future anti-malarial drug development.