Morphologically homogeneous, pH-responsive gold nanoparticles for non-invasive imaging of HeLa cancer

• DOI: 10.1016/j.nano.2021.102394
• Publication Date: 2021-04-14T02:20:19Z
• Authors: Min Su Yim; Yeon Sil Hwang; Jeong Kyu Bang; Dae-Woong Jung; Jun Min Kim; Gi-Ra Yi; Gaehang Lee; Eun Kyoung Ryu
• Keywords: HeLa; Nanocarriers; Linker; Biocompatibility; Surface Modification

Gold nanoparticles (AuNPs) have been widely used as nanocarriers in drug delivery to improve the efficiency of chemotherapy treatment and enhance early disease detection. The advantages AuNPs include their excellent biocompatibility, easy modification functionalization, facile synthesis, low toxicity, controllable particle size. This study aimed synthesize a conjugated citraconic anhydride link between morphologically homogeneous doxorubicin (DOX) (DOX-AuNP). carrier was radiolabeled for tumor diagnosis using positron emission tomography (PET). systemically designed DOX-AuNP cleaved at linker site under mild acidic conditions cancer cell, thereby releasing DOX. Subsequently, aggregated via electrostatic attraction. HeLa cells exhibited high uptake DOX-AuNP. Moreover, PET images were obtained xenograft mouse models. Therefore, is expected provide valuable insight into use radioligands detect tumors PET.