Platelet–neutrophil hybrid membrane-coated gelatin nanoparticles for enhanced targeting ability and intelligent release in the treatment of non-alcoholic steatohepatitis

• DOI: 10.1016/j.nano.2022.102538
• Publication Date: 2022-02-18T01:47:24Z
• Authors: Wei Xie; Pengpeng Liu; Fei Gao; Yang Gu; Yushao Xiao; Ping Wu; Baiyang Chen; Wei Liu; Quanyan Liu
• Keywords: Gelatin; Steatohepatitis; Alcoholic Hepatitis

Non-alcoholic steatohepatitis (NASH) is the major form of chronic liver disease in adults; however, there are no approved drugs for NASH. In this study, we designed PNM-G-PV method, which gelatin nanoparticles (G) loaded with pioglitazone and vitamin E (G-PV) then encapsulated by surfaces platelet–neutrophil hybrid membranes (PNM). Inherited from natural source cells, PNM show immune evading ability due to surface marker comprising a number "do not eat me" signals has dual inflammatory enrichment capabilities specific adhesion molecules. By functionalizing nanoparticle biomimetic surfaces, PNM-G can enhance targeting sites enrich tissue. The high expression matrix metalloproteinase-9 (MMP-9) at NASH site enables intelligently respond degradation release drug treatment. We performed an vivo analysis these monitor changes triacylglycerol metabolism tissues assessed therapeutic efficacy rat model. results showed that exhibited better than therapies using G-PV or PV alone. This work explores new biomedical use promising treatment protocol based on delivery system.