Specific nanoarchitecture of silica nanoparticles codoped with the oppositely charged Mn2+ and Ru2+ complexes for dual paramagnetic-luminescent contrasting effects

• DOI: 10.1016/j.nano.2023.102665
• Publication Date: 2023-02-22T07:30:38Z
• Authors: Svetlana Fedorenko; Alexey Stepanov; Olga Bochkova; Kirill Kholin; Irek Nizameev; Alexandra Voloshina; Oksana Tyapkina; Dmitry Samigullin; Sofiya Kleshnina; Bulat Akhmadeev; Alexander Romashc...; Evgenii Zavjalov; Rustem Amirov; Asiya Mustafina
• Keywords: Mice; Animals; Nanoparticles; Contrast Media; Tissue Distribution; 02 engineering and technology; Silicon Dioxide; 0210 nano-technology; Magnetic Resonance Imaging

The silica nanoparticles (SNs) co-doped with paramagnetic ([Mn(HL)]n-,) and luminescent ([Ru(dipy)3]2+) complexes are represented. The specific distribution of [Mn(HL)]n- within the SNs allows to achieve about ten-fold enhancing in magnetic relaxivities in comparison with those of [Mn(HL)]n- in solutions. The leaching of [Mn(HL)]n- from the shell can be minimized through the co-doping of [Ru(dipy)3]2+ into the core of the SNs. The co-doped SNs exhibit colloid stability in aqueous solutions, including those modeling a blood serum. The surface of the co-doped SNs was also decorated by amino- and carboxy-groups. The cytotoxicity, hemoagglutination and hemolytic activities of the co-doped SNs are on the levels convenient for "in vivo" studies, although the amino-decorated SNs cause more noticeable agglutination and suppression of cell viability. The co-doped SNs being intravenously injected into mice allows to reveal their biodistribution in both ex vivo and in vivo conditions through confocal microscopy and magnetic resonance imaging correspondingly.