Interleukin-6 as a prognostic marker in acute kidney injury and its klotho-dependent regulation

• DOI: 10.1016/j.nefroe.2024.11.010
• Publication Date: 2024-11-29T12:53:17Z
• Authors: Laura González-La...; Elisa Mercado-García; Sara Vázquez-Sánchez; Daniel González-M...; Lisardo Boscá; María Fernández-V...; Julián Segura; Makoto Kuro-O; Luis M. Ruilope; Fernando Liaño; Gema Ruiz-Hurtado
• Keywords: Klotho

In acute kidney injury (AKI), a strong inflammatory component is activated in response to the renal damage, and one of main mediators behind this process pro-inflammatory interleukin 6 or IL-6. Beside phenomenon, there are also alterations different components mineral metabolism, such as those dependent on fibroblast growth factor (FGF)23 anti-ageing cofactor klotho. The aim work was explore association between function systemic levels IL-6, well FGF23 klotho early stages AKI, analysing predictive capacity IL-6 mortality associated with AKI. Plasma were analysed samples from 28 patients AKI related hospital admission, after 24 72 h. addition, AKI-associated at three study time points. an experimental nephrotoxic -AKI mouse model, values h induction mice overexpressing protein, Systemic increased patients, especially admission time, decreased parallel improving function. At same increased, increase decrease levels, significant positive correlation levels. we obtained that good predictor these area under curve equal observed plasma both damage. Nevertheless, transgenic klotho, no any them. There damage time. Moreover, able predict being promising prognostic biomarker prediction patient admission. Maintaining adequate could prevent mediated therefore reduce degree severity