SAMSN1 Is a Tumor Suppressor Gene in Multiple Myeloma

• DOI: 10.1016/j.neo.2014.07.002
• Publication Date: 2014-08-09T21:46:07Z
• Authors: Jacqueline E. Noll; Duncan R. Hewett; Sharon A. Williams; Kate Vandyke; Chung Kok; Luen B. To; Andrew C.W. Zanne...
• Keywords: Male; 0301 basic medicine; 570; DNA Mutational Analysis; Gene Expression; Monoclonal Gammopathy of Undetermined Significance; Article; Mice; 03 medical and health sciences; Cell Line, Tumor; Gene Order; Animals; Humans; Genes, Tumor Suppressor; Tumor suppressor gene; RC254-282; Gene Expression Profiling; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Chromosome Mapping; DNA Methylation; Adaptor Proteins, Vesicular Transport; Alternative Splicing; Disease Models, Animal; Genetic Loci; Disease Progression; Female; Gene Deletion

Multiple myeloma (MM), a hematological malignancy characterized by the clonal growth of malignant plasma cells (PCs) in bone marrow, is preceded benign asymptomatic condition, monoclonal gammopathy undetermined significance (MGUS). Several genetic abnormalities have been identified as critical for development MM; however, number these are also found patients with MGUS, indicating that there other, yet unidentified, factors contribute to onset MM disease. In this study, we identify Samsn1 gene deletion 5TGM1/C57BL/KaLwRij murine model myeloma. addition, SAMSN1 expression reduced CD138 + PCs and correlates total PC burden. We promoter methylation potential mechanism through which modulated human cell lines. Notably, re-expression 5TGM1 line resulted complete inhibition disease vivo decreased proliferation stromal cell–PC co-cultures vitro. This first study key C57BL/KaLwRij mice displays therefore likely play an integral role development.