Reciprocal Interaction between Carcinoma-Associated Fibroblasts and Squamous Carcinoma Cells through Interleukin-1α Induces Cancer Progression

• DOI: 10.1016/j.neo.2014.09.003
• Publication Date: 2014-11-20T18:03:09Z
• Authors: Jung Yoon Bae; Eun Kyoung Kim; Dong Hyun Yang; Xianglan Zhang; Young-Jin Park; Doo Young Lee; Chung Min Che; Jin Kim
• Keywords: Cancer-Associated Fibroblasts; CXCL1; Tumor progression

Crosstalk between cancer cells and carcinoma-associated fibroblasts (CAFs) has earned recognition as an interaction that plays a pivotal role in carcinogenesis. Thus, we attempted to clarify whether increase the level of CAFs promotes progression by proportionally enhancing CAFs. We first analyzed clinical correlation levels found made noticeable difference on prognosis patients with oral squamous cell carcinoma (OSCC). In vivo animal study also demonstrated tumor volume depended dose was co-injected OSCC cells. The same tendency observed vitro study. interleukin-1α (IL-1α) secreted from had dual effects CAFs: IL-1α not only promoted proliferation but upregulated secretion cytokines such CCL7, CXCL1, IL-8. induction activity cytokine surpassed summary, unraveled important interactive mechanism carcinogenesis: released stimulates simultaneous human OSCC. On basis these findings, propose is eligible for being selected prognostic factor will be useful routine diagnosis. blockage reciprocal provide insight developing novel chemotherapeutic strategy.