H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells

• DOI: 10.1016/j.neo.2016.10.007
• Publication Date: 2017-02-08T09:01:19Z
• Authors: Shanwen Chen; Dingfang Bu; Yuanyuan Ma; Jing Zhu; Guowei Chen; Lie Sun; Shuai Zuo; Tengyu Li; Yisheng Pan; Xin Wang; Yucun Liu; Pengyuan Wang
• Keywords: HMGA2

The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types cancer. However, role colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between and vitamin D receptor (VDR) signaling. Considering pivotal VDR signaling epithelium both physiologically pathologically, correlation may have an important development In this study, underlying mechanisms were investigated vitro vivo. results that able to inhibit expression through regulating C-Myc/Mad-1 network. H19, on other hand, micro 675-5p (miR-675-5p). Furthermore, overexpression induced resistance treatment with 1,25(OH)2D3 Together, these might be one advanced stage