Estimulación cerebral profunda en pacientes parkinsonianos con intolerancia a levodopa

• DOI: 10.1016/j.neucir.2017.09.005
• Publication Date: 2017-10-29T00:45:13Z
• Authors: Pedro J. García-Ruiz; Cici Feliz-Feliz; Joaquín Ayerbe Gr...; José Matías Arbelo; Carlos Salvador; Javier Del Val Fe...; Juan García-Calde...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Deep brain stimulation (DBS) is at present, a useful treatment for patients with advanced Parkinson's disease and motor complications. The crucial step toward consistent DBS outcomes remains careful patient selection; several conditions must be fulfilled including excellent levo dopa response. We report two cases of early onset Parkinson's disease with severe intolerance to levo dopa but excellent and sustained response to DBS. DBS can be a useful alternative for parkinsonian patients with severe intolerance to levo dopa, provided a positive acute response to levo dopa or apomorphine is obtained.